MovDisordV3, Main, Exploration, bibRecord, 002F65

Cerebrospinal fluid hypocretin‐1 levels in multiple system atrophy

Identifieur interne : 002F65 ( Main/Exploration ); précédent : 002F64; suivant : 002F66

Cerebrospinal fluid hypocretin‐1 levels in multiple system atrophy

Auteurs : Jose Enrique Martinez-Rodriguez [Espagne] ; Klaus Seppi [Autriche] ; Adriana Cardozo [Espagne] ; Alex Iranzo [Espagne] ; Michaela Stampfer-Kountchev [Autriche] ; Gregor Wenning [Autriche] ; Eduardo Tolosa [Espagne] ; Birgit Högl [Autriche] ; Joan Santamaria [Espagne] ; Werner Poewe [Autriche]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-09-15.

RBID : ISTEX:9A1C890FE991B101EBEC863232F2035AD7D8B142

English descriptors

KwdEn :
- Aged, Female, Humans, Intracellular Signaling Peptides and Proteins (cerebrospinal fluid), Male, Middle Aged, Multiple System Atrophy (cerebrospinal fluid), Multiple System Atrophy (physiopathology), Neuropeptides (cerebrospinal fluid), hypocretin, multiple system atrophy, orexin.
MESH :
- chemical , cerebrospinal fluid : Intracellular Signaling Peptides and Proteins, Neuropeptides.
- cerebrospinal fluid : Multiple System Atrophy.
- physiopathology : Multiple System Atrophy.
- Aged, Female, Humans, Male, Middle Aged.

Abstract

Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin‐1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin‐1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/9A1C890FE991B101EBEC863232F2035AD7D8B142/fulltext/pdf

DOI: 10.1002/mds.21668

Affiliations:

Le document en format XML

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<author><name sortKey="Martinez Odriguez, Jose Enrique" sort="Martinez Odriguez, Jose Enrique" uniqKey="Martinez Odriguez J" first="Jose Enrique" last="Martinez-Rodriguez">Jose Enrique Martinez-Rodriguez</name>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
</author>
<author><name sortKey="Cardozo, Adriana" sort="Cardozo, Adriana" uniqKey="Cardozo A" first="Adriana" last="Cardozo">Adriana Cardozo</name>
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<author><name sortKey="Iranzo, Alex" sort="Iranzo, Alex" uniqKey="Iranzo A" first="Alex" last="Iranzo">Alex Iranzo</name>
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<author><name sortKey="Stampfer Ountchev, Michaela" sort="Stampfer Ountchev, Michaela" uniqKey="Stampfer Ountchev M" first="Michaela" last="Stampfer-Kountchev">Michaela Stampfer-Kountchev</name>
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<author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name>
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<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
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<author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name>
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<author><name sortKey="Santamaria, Joan" sort="Santamaria, Joan" uniqKey="Santamaria J" first="Joan" last="Santamaria">Joan Santamaria</name>
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<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
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<front><div type="abstract" xml:lang="en">Hypocretin (orexin) cerebrospinal fluid (CSF) levels have been previously found normal or decreased in Dementia with Lewy bodies and Parkinson disease, two synucleinopathies commonly associated with excessive daytime sleepiness (EDS). We evaluated CSF hypocretin‐1 levels in 15 patients with moderately severe multiple system atrophy (MSA), another synucleinopathy where sleep disorders occur frequently and EDS has been reported, performing additional electrophysiological studies in 5 of them to assess the presence of EDS and sleep onset REM (SOREM) periods. Despite relatively low sleep efficiencies in nocturnal sleep, mean sleep latencies in the Multiple Sleep Latency Test were normal with no SOREM periods. All patients had CSF hypocretin‐1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Cerebrospinal fluid hypocretin‐1 levels in multiple system atrophy

Cerebrospinal fluid hypocretin‐1 levels in multiple system atrophy

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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